Waec Model Questions Vol1 2019 Biology Question 5
Practice objective / multiple choice question 5 from the 2019 Waec Model Questions Vol1 Biology examination.
Drug Z has an oral bioavailability of 0.6, a volume of distribution of 40 L, and an elimination half‑life of 8 h. It is administered every 12 h. (a) What loading dose (in mg) is required to instantly achieve a plasma concentration of 5 µg·mL⁻¹? (b) What maintenance dose (in mg) should be given each interval to maintain a steady‑state peak concentration of 5 µg·mL⁻¹, assuming first‑order kinetics? (c) If a patient's renal clearance falls by 30%, how should the maintenance dose be adjusted to keep the same steady‑state concentration?
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This is Waec Model Questions Vol1 2019 Biology Question 5. It is one of the objective questions from the 2019 Waec Model Questions Vol1 Biology examination.
Difficulty level: Hard .
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