Neco Model Questions Vol1 2024 Biology Question 33
Practice objective / multiple choice question 33 from the 2024 Neco Model Questions Vol1 Biology examination.
A 70 kg patient requires a drug that is dosed at \(5\) mg kg⁻¹ day⁻¹, given in two equal oral doses. The drug follows first‑order elimination with a half‑life of \(6\) h, has a volume of distribution \(V_d = 0.6\) L kg⁻¹ and a total clearance \(Cl = 0.1\) L kg⁻¹ h⁻¹. Using a dosing interval of \(\tau = 12\) h, calculate the steady‑state peak plasma concentration \(C_{max,ss}\) (in mg L⁻¹). Use the equation \[C_{max,ss}=\frac{\text{Dose}/\tau}{Cl}\times\frac{1}{1-e^{-k\tau}}\] where \(k = \frac{\ln 2}{t_{1/2}}\).
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This is Neco Model Questions Vol1 2024 Biology Question 33. It is one of the objective questions from the 2024 Neco Model Questions Vol1 Biology examination.
Difficulty level: Hard .
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