Gce Model Questions Vol1 2025 Biology Question 7
Practice objective / multiple choice question 7 from the 2025 Gce Model Questions Vol1 Biology examination.
A drug has an elimination half‑life of 6 h, oral bioavailability \(F = 0.8\), and a volume of distribution \(V_d = 40\) L. It is administered every 8 h at a dose \(D\) mg. At steady state the peak (just after dosing) concentration is given by \(C_{\text{max}} = \frac{F D}{V_d}\frac{1}{1-e^{-k\tau}}\) and the trough concentration just before the next dose is \(C_{\text{min}} = C_{\text{max}}e^{-k\tau}\), where \(k = \frac{\ln 2}{\text{half‑life}}\) and \(\tau = 8\) h. The therapeutic window requires \(C_{\text{min}} \ge 2\) µg mL\(^{-1}\) and \(C_{\text{max}} \le 10\) µg mL\(^{-1}\). What is the maximum whole‑milligram dose \(D\) that satisfies both constraints?
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This is Gce Model Questions Vol1 2025 Biology Question 7. It is one of the objective questions from the 2025 Gce Model Questions Vol1 Biology examination.
Difficulty level: Hard .
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