Gce Model Questions Vol1 2024 Biology Question 10

Practice essay / theory question 10 from the 2024 Gce Model Questions Vol1 Biology examination. This question covers Mendelian inheritance, Autosomal recessive disorders, Genetic linkage, Recombination frequency, Genetic counselling .

Gce Model Questions Vol1 2024 Biology Essay / Theory
Topics: Mendelian inheritance Autosomal recessive disorders Genetic linkage Recombination frequency Genetic counselling
Question 10 GCE_MODEL_QUESTIONS_VOL1 • 2024 • BIOLOGY • essay

A pedigree shows a family in which a rare autosomal recessive disorder appears in two siblings but not in their parents. The disorder is caused by a mutation in gene X on chromosome 12. Gene X is linked to a marker locus M with a recombination frequency of 10 %. The marker alleles are M1 and M2. Affected children are homozygous recessive (xx).

Question Parts

( a )
Determine the most probable genotype of the parents for gene X and the marker locus M.
( b )
Assuming no crossing‑over between X and M, calculate the probability that a child born to these parents will be affected by the disorder.
( c )
Discuss how the 10 % recombination frequency modifies the probability obtained in part (b) and the implications for genetic counselling of this family.

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About This Question

This is Gce Model Questions Vol1 2024 Biology Question 10. It is one of the essay questions from the 2024 Gce Model Questions Vol1 Biology examination.

The question covers Mendelian inheritance, Autosomal recessive disorders, Genetic linkage, Recombination frequency, Genetic counselling .

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