Gce Model Questions Vol1 2020 Biology Question 5
Practice objective / multiple choice question 5 from the 2020 Gce Model Questions Vol1 Biology examination.
An oral antibiotic follows a one‑compartment model with first‑order elimination. Its volume of distribution is \(V_d = 40\) L, elimination half‑life \(t_{1/2} = 6\) h, and oral bioavailability \(F = 0.8\). The drug is to be given every \(\tau = 8\) h. The desired steady‑state peak concentration is \(C_{max,ss}=15\) µg·mL⁻¹ and the trough should be at least \(5\) µg·mL⁻¹. Determine the oral dose (in milligrams) required to meet these targets and calculate the accumulation factor \(R = \frac{1}{1-e^{-k\tau}}\). Give the dose to the nearest whole milligram and the accumulation factor to two decimal places.
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This is Gce Model Questions Vol1 2020 Biology Question 5. It is one of the objective questions from the 2020 Gce Model Questions Vol1 Biology examination.
Difficulty level: Hard .
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