Igcse Model Questions Vol1 2019 Biology Question 10

Practice essay / theory question 10 from the 2019 Igcse Model Questions Vol1 Biology examination. This question covers Pedigree analysis, Mendelian inheritance, Probability of genetic traits, Genetic variation .

Igcse Model Questions Vol1 2019 Biology Essay / Theory
Topics: Pedigree analysis Mendelian inheritance Probability of genetic traits Genetic variation
Question 10 IGCSE_MODEL_QUESTIONS_VOL1 • 2019 • BIOLOGY • essay

In a small community, a hereditary disorder shows the following pattern over three generations: - Generation I: Affected male (II-1) marries an unaffected female. - Generation II: Their two children, a son (III-1) and a daughter (III-2), are both unaffected. - Generation III: The son (III-1) marries an unaffected female and has two children, both affected. The daughter (III-2) marries an unaffected male and has one child, who is unaffected. No other family members are reported to have the disorder.

Question Parts

( a )
Identify the most likely mode of inheritance for this disorder and justify your answer using the information given.
( b )
Assuming the disorder is autosomal recessive, calculate the probability that two unaffected carriers (both heterozygous) will have a child who is (i) affected, (ii) a carrier, and (iii) completely free of the mutant allele.
( c )
Explain how crossing‑over during meiosis contributes to genetic variation and discuss how it could affect the frequency of this disorder in future generations.

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About This Question

This is Igcse Model Questions Vol1 2019 Biology Question 10. It is one of the essay questions from the 2019 Igcse Model Questions Vol1 Biology examination.

The question covers Pedigree analysis, Mendelian inheritance, Probability of genetic traits, Genetic variation .

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