In a study on the genetic basis of antibiotic resis ance in bacteria, researchers isolated a strain of E. coli that exhibited high-level resis ance to ampicillin. The researchers sequenced the bacterial genome and identified a point mutation in the gene encoding the \beta-lactamase enzyme, which is responsible for conferring resis ance to ampicillin. The mutation resulted in a change from glutamic acid to valine at position 240 of the enzyme. What is the likely effect of this mutation on the enzyme's activity?

Question

In a study on the genetic basis of antibiotic resis	ance in bacteria, researchers isolated a strain of E. coli that exhibited high-level resis	ance to ampicillin. The researchers sequenced the bacterial genome and identified a point mutation in the gene encoding the \beta-lactamase enzyme, which is responsible for conferring resis	ance to ampicillin. The mutation resulted in a change from glutamic acid to valine at position 240 of the enzyme. What is the likely effect of this mutation on the enzyme's activity?

Accepted Answer

The mutation will increase the enzyme's activity, leading to increased resis	ance to ampicillin.

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